MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9BF5B.1D8626F0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Windows® Internet Explorer®. ------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Extended haplotype of the CTLA4 gene within the coeliac patients in = the Maltese population.

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nDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkA nDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEA nDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEA nDEAnDkAnDEAnDEAnDEAnDkAnDEAnDEAnDEAnDkAAwAAAAAA ------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/master72.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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‹#› ------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/master72.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Extended haplotype of the CTLA4 gene within the coeliac patients in = the Maltese population.
Extended haplotype of the CTLA4 gene = within = the coeliac patients in the Maltese population.
Karen Muscat
MSc Pat= hology (Molecular Biology and H  Haemato= logy)
Supervisor: Dr Christian A. Scerri
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Coeliac= Disease
nalso known as coeliac sprue, non-tropical sprue, and gluten-sensitive enteropathy
nan inflammatory disease of the upp= er small in= testine
nresults from gluten ingestion in genetically su= sceptible individuals (Cooke and Holmes, 1984). &#= 13;
nis a common, polygenic and multifactorial disorder that may serve as a model for the study of inflammatory diseases (Louka and Sollid, 2= 003).
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Prevalence of Coeliac Disease
<= span style=3D'font-size:75%;color:yellow;text-shadow:auto;visibility:hidden'>n<= span style=3D'font-size:75%;text-shadow:auto;color:yellow;display:none'>
= n Was thought to be uncommon, but du= e to the greater awareness of its presentation and the availability of accurate serologic tests it was realised that the disorder is relatively common, affecting 1 in every 120 to 300 persons (Not et al., 1998). =
<= span style=3D'font-size:75%;color:yellow;text-shadow:auto;visibility:hidden'>n<= span style=3D'font-size:75%;text-shadow:auto;color:yellow;display:none'>
= nPrevalence of coeliac disease among Finnish school children is at least 1 case in 99 children (Maki et a= l., 2003). =
n
nDue to the variabili= ty in presentation of the disease, particularly in patients that have l= ittle or no symptoms the true prevalence of CD is difficult to estimate (Feldman et a= l., 2003).
------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/slide0004.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Extended haplotype of the CTLA4 gene within the coeliac patients in = the Maltese population.
<= p:shaperange href=3D"master58.xml#_x0000_m1031"/>
The coeliac iceberg<= /span>
n
<= span style=3D'color:yellow;text-shadow:auto;visibility:hidden'>n<= span lang=3DEN-GB style=3D'text-shadow:auto;color:yellow;display:none'>
<= span style=3D'color:yellow;text-shadow:auto;visibility:hidden'>n<= span lang=3DEN-GB style=3D'text-shadow:auto;color:yellow;display:none'>
n        = ;            &n= bsp;        Source: Fraser and Ciclitira, 2001
<= ![if !vml]>
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Maltese population.
Prevalence of Coeliac Disease
n historically considered to be a childhood disorder
n the screening programmes have show= n that it can present at any age and is now more predominately diagnosed during the= early middle age period.
nfemales are more com= monly affected than males (Feighery et al., 1998).
nthe most common food intolerance in the world (Accomando and Cataldo, 2004).
------=_NextPart_01C9BF5B.1D8626F0 Content-Location: file:///C:/4A861A53/ctla4andicos_files/slide0006.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Extended haplotype of the CTLA4 gene within the coeliac patients in = the Maltese population.
Pathogenesis of coel= iac disease
<= span style=3D'font-size:57%;color:yellow;text-shadow:auto;visibility:hidden'>n<= span style=3D'font-size:57%;text-shadow:auto;color:yellow;display:none'>
<= span style=3D'font-size:57%;color:yellow;text-shadow:auto;visibility:hidden'>n<= span style=3D'font-size:57%;text-shadow:auto;color:yellow;display:none'>
<= span style=3D'font-size:71%;color:yellow;text-shadow:auto;visibility:hidden'>n<= span style=3D'font-size:71%;text-shadow:auto;color:yellow;display:none'>
nDigestion breaks down gluten (A) into peptides (B) that are absorbed by the small intestine. The= re, the enzyme tissue transglutaminase (C) modifies certain = peptides, which are = picked up by dendritic cells and, in people with celiac = disease, stimulate i= mmune cells (D) to attack the intestine.
Source: http://abdellab.sunderland.ac.uk
<= ![if !vml]>3D"Celiac_Khosla"
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